A POWERFUL RESEARCH AND
                  DEVELOPMENT ENGINE

                  Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.

                  • Phase 1 trials Phase 1 trials

                    Phase 1 Trials

                    CEMIPLIMAB*

                    PD-1 Antibody Cancer

                    REGN3767

                    LAG-3 Antibody Cancer

                    REGN1979

                    CD20xCD3 Antibody Cancer

                    REGN4018*

                    MUC16xCD3 Antibody Cancer

                    REGN4659

                    CTLA4 Antibody Cancer
                    REGN5093
                    METxMET Antibody Cancer

                    REGN5458*

                    BCMAxCD3 Antibody Cancer
                    REGN5459*
                    BCMAxCD3 Antibody Cancer
                    REGN5678
                    PSMAxCD28 Antibody Cancer

                    REGN3048-3051

                    Middle East Respiratory Coronavirus Antibody MERS-CoV infection

                    REGN4461

                    LEPR Antibody Lipodystrophy and obesity
                    REGN5713-5714-5715
                    Betv1 Antibody Birch Allergy
                  • Phase 2 trials Phase 2 trials

                    Phase 2 Trials

                    AFLIBERCEPT
                    VEGF Trap High-dose for wet age-related macular degeneration (AMD)

                    CEMIPLIMAB*

                    PD-1 Antibody Basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC)
                    REGN1979
                    CD20xCD3 Antibody Relapsed/refractory follicular lymphoma

                    DUPILUMAB*

                    IL-4R Antibody Grass allergy, peanut allergy

                    SARILUMAB*

                    IL-6R Antibody Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis

                    REGN1908-1909

                    Fel d 1 Antibody Cat allergy

                    REGN3500*

                    IL-33 Antibody Asthma, chronic obstructive pulmonary disease (COPD), atopic dermatitis

                    REGN5069

                    GFRα3 Antibody Osteoarthritis knee pain

                    GARETOSMAB

                    Activin A Antibody Fibrodysplasia Ossificans Progressiva (FOP)

                    EVINACUMAB

                    ANGPTL-3 Antibody Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia

                    POZELIMAB

                    C5 Antibody Paroxysmal nocturnal hemoglobinuria
                  • Phase 3 trials Phase 3 trials

                    Phase 3 Trials

                    AFLIBERCEPT
                    VEGF Trap Retinopathy of Prematurity (ROP)

                    ALIROCUMAB*

                    PCSK9 Antibody Homozygous familial hypercholesterolemia (HoFH) in adults and pediatrics, heterozygous familial hypercholesterolemia in pediatrics

                    CEMIPLIMAB*

                    PD-1 Antibody Non-small cell lung cancer (NSCLC), cervical cancer, cutaneous squamous cell carcinoma (CSCC) (adjuvant)

                    REGN-EB3

                    Ebola Virus Antibody Ebola virus infection

                    DUPILUMAB*

                    IL-4R Antibody Atopic dermatitis in pediatrics, asthma in pediatric, eosinophilic esophagitis, COPD

                    SARILUMAB*

                    IL-6R Antibody Polymyalgia rheumatica, giant cell arteritis

                    EVINACUMAB

                    ANGPTL-3 Antibody Homozygous familial hypercholesterolemia (HoFH)

                    FASINUMAB?

                    NGF Antibody Chronic pain from osteoarthritis of the knee or hip
                  • IMMUNOLOGY & INFLAMMATORY DISEASES
                  • ONCOLOGY
                  • OPHTHALMOLOGY
                  • RARE DISEASES
                  • CARDIOVASCULAR/METABOLIC DISEASES
                  • INFECTIOUS DISEASES
                  • PAIN

                  Trials Footnotes

                  * in collaboration with Sanofi

                  ? in collaboration with Teva and Mitsubishi Tanabe

                  This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.

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